After entering the host cell nucleus, the double-stranded viral DNA is integrated into the human DNA. This may then direct the synthesis of viral messenger RNA, which leaves the nucleus and enters the cytoplasm, with instructions to produce viral proteins.
Double-stranded viral DNA enters the host cell nucleus
through pores in the nuclear membrane. Another viral enzyme, integrase, then inserts the
double-stranded viral DNA at random into the DNA of the host. The viral DNA then becomes
integrated into the human DNA, turning the host cell into a "factory" for
manufacturing more virus.