Mutations & Resistance in HIV

Managing Resistance to HIV Therapy
- Causes of Treatment Failure
- Rational Treatment Sequencing
- Treatment Choices
- Hidden Dangers?
- Resistance Studies
- Measuring Resistance

Resistance Quiz

References

Credits

Resistance Studies
The patterns of mutations in the HIV-1 pol gene that arise during treatment with nucleoside analogues, non-nucleoside reverse transcriptase inhibitors and protease inhibitors are well known from monotherapy studies. However, the patterns that emerge during combination therapy do not always represent the sum of the monotherapy mutations. These reasons for these differences need to be explored.

In general, genotypic (genetic) changes correlate well with phenotypic (physical characteristics) measurements of drug sensitivity, although resistance to one drug can sometimes be at least partly reversed by additional mutations selected by a second drug. So far there have been no studies of the use of resistance to guide treatment decisions.

Measuring Resistance