HIV Adherence Studies
In HIV infected people taking zidovudine, factors that have been found to influence adherence include19,20:
In one study, people taking more than 3 times daily dosing, or an average of more than 4.5 medications, were significantly less adherent than those on twice daily regimens and fewer medications. Knowledge about medication was associated with improved adherence17.
People with HIV may be symptom free in the early stages of the disease, so the results of non-adherence may not be evident until much later21. Non-adherence is more common among people with psychological distress, depression and poor adaptive and coping mechanisms. People with HIV who have had opportunistic infections are more likely to adhere to therapy20. Taken together, these findings underline the challenges of starting complex multi-drug regimens for people with asymptomatic disease who may still be coming to terms with their HIV positivity.