Dosing Schedule and Adherence
Morning doses are more reliably taken than evening doses11. With twice daily antihypertensive drugs fewer than half the doses were taken within 12 + 2 hours12. Timing of doses may be particularly important for people receiving protease inhibitors, which remain active in the body for a relatively short time. In people who missed only a few days of saquinavir the viral load in the blood rose rapidly, and the virus became resistant to the drug13.
Treatment recommendations are best tailored to an individual's own expectations and their own assessment of their ability to manage different dosing schedules (eg, twice daily versus three times daily) and dietary requirements for the different drugs (eg, having to take them with or without food). See Adherence issues for examples.